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DeCS
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Descriptor English:
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Antineoplastic Agents, Alkylating
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Descriptor Spanish:
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antineoplásicos alquilantes
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Descriptor Portuguese:
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Antineoplásicos Alquilantes
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Synonyms English:
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Alkylating Agents, Antineoplastic
Alkylating Antineoplastic Agents
Alkylating Antineoplastic Drugs
Alkylating Antineoplastics
Alkylating Drugs, Antineoplastic
Antineoplastic Alkylating Agents
Antineoplastic Alkylating Drugs
Antineoplastic Drugs, Alkylating
Antineoplastics, Alkylating
Drugs, Antineoplastic Alkylating
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Tree Number:
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D27.505.519.124.035
D27.505.954.248.150
D27.888.569.035.035
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Definition English:
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A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026) |
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History Note English:
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96
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Allowable Qualifiers English:
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Record Number:
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32836
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Unique Identifier:
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D018906
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Occurrence in VHL:
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Similar:
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DeCS
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